TABLE 6.

Amino acid sequences of the Cyp binding region in CA of HIV-2 strains

Virus	Subtype	CA sequence at amino acida:															Debio-025 IC50 (μM)
		85	86	87	88	89	90	91	92	93	94	95	96	97	98	99
Consensus sequence	HIV-2 A	P	I	P	*	G	P	L	P	A	G	Q	L	R	E/D	P	NDb
CDC310319	HIV-2	—	L/W	—	*	—	—	M	—	—	—	—	—	—	—	—	10.52
CDC310342	HIV-2	—	V	H	A	—	—	I	—	P	—	—	M	—	—	—	0.058
92RW016	HIV-1 A	—	V	H	A	—	—	I	—	P	—	—	M	—	—	—	0.008

^a*, no amino acid. L/W and E/D, mixed populations.

^bND, not determined.