TABLE 3.
Comparative toxicities of 2-aminosuberic acid derivatives against two P. falciparum strains versus a normal cell linea
R1, R2, and X refer to variable groups on the compound shown in Fig. 1.
IC50 values for 3D7 versus Dd2 were significantly different for compounds 7 (P = 0.015) and 11 (P = 0.016) but not for the remaining compounds (P > 0.05).
Selectivity index was calculated as the difference between P. falciparum and mammalian cells (neonatal foreskin fibroblast cell [NFF] toxicity IC50 values/IC50 of P. falciparum).