TABLE 3.

Comparative toxicities of 2-aminosuberic acid derivatives against two P. falciparum strains versus a normal cell line^a

^aR¹, R², and X refer to variable groups on the compound shown in Fig. 1.

^bIC₅₀ values for 3D7 versus Dd2 were significantly different for compounds 7 (P = 0.015) and 11 (P = 0.016) but not for the remaining compounds (P > 0.05).

^cSelectivity index was calculated as the difference between P. falciparum and mammalian cells (neonatal foreskin fibroblast cell [NFF] toxicity IC₅₀ values/IC₅₀ of P. falciparum).