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. 2008 Jan 22;52(4):1454–1461. doi: 10.1128/AAC.00757-07

TABLE 3.

Comparative toxicities of 2-aminosuberic acid derivatives against two P. falciparum strains versus a normal cell linea

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a

R1, R2, and X refer to variable groups on the compound shown in Fig. 1.

b

IC50 values for 3D7 versus Dd2 were significantly different for compounds 7 (P = 0.015) and 11 (P = 0.016) but not for the remaining compounds (P > 0.05).

c

Selectivity index was calculated as the difference between P. falciparum and mammalian cells (neonatal foreskin fibroblast cell [NFF] toxicity IC50 values/IC50 of P. falciparum).