FIG. 5.

Suppression of MAV-1 infection in SCID mice receiving virus-specific IgG. Immunocompetent BALB/c mice were challenged with MAV-1, and at 15 and 43 d.p.i., the IgG fractions (designated IgG15 and IgG43, respectively) were isolated from pooled immune sera. Nonimmune IgG was obtained from noninfected BALB/c mice. MAV-1-neutralizing IgG titers were determined by a virus neutralization assay (see inset). Nonimmune IgG, IgG15 (mean titer, 1:130), or IgG43 (mean titer, 1:3,750) was transferred into SCID mice by i.p. injection (in a 200-μl volume) 1 day before and 9 days after infection with MAV-1. Data for each treatment condition were compiled from the results of two independent experiments, each including five mice per group.