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Nucleosome modification and chromatin remodeling can regulate the ORF50 promoter during reactivation signals. Sp1 binds ORF50 near the transcription initiation site and within the boundary of the nucleosome. Histone acetylation caused by NaB, TSA, or ectopic expression of CBP leads to nucleosome remodeling and transcription activation. Contributions from unknown additional factors are represented by question marks.
