TABLE 1.
Summary of MICs of various antifungal agents alone and in combination against C. krusei ATCC 6258, as reported by the eight participating laboratoriesa
| Antifungal agent(s) | MIC (μg/ml)
|
MIC50 (drug A/drug B [μg/ml])
|
MIC100 (drug A/drug B [μg/ml])
|
|||
|---|---|---|---|---|---|---|
| Range | Mode | Range | Mode | Range | Mode | |
| AMB | 1.0-2.0 | 1 | ||||
| PSC | 0.12-0.5 | 0.25 | ||||
| CSP | 0.25-1.0 | 0.5 | ||||
| VRC | 0.12-0.5 | 0.25 | ||||
| AMB + PSC | 0.06-1.0/0.008-0.5 | 0.5/0.06 | 0.25-1.0/0.008-0.25 | 1.0/0.25 | ||
| AMB + CSP | 0.015-1.0/0.03-1.0 | 0.5/0.25 | 0.12-1.0/0.03-1.0 | 0.5/0.5 | ||
| AMB + VRC | 0.015-1.0/0.008-0.25 | 1/0.008 | 2.0/0.008-0.5 | 2.0/0.008 | ||
| PSC + CSP | 0.008-0.25/0.03-0.25 | 0.25/0.12 | 0.008-0.25/0.5-1.0 | 0.008/1.0 | ||
| PSC + VRC | 0.008-0.25/0.008-0.25 | 0.008/0.25 | 0.12-0.5/0.008-0.5 | 0.5/0.5 | ||
| VRC + CSP | 0.008-0.25/0.03-0.5 | 0.008/0.25 | 0.008-0.06/1.0-2.0 | 0.008/1.0 | ||
a
Values are based on 10 replicate determinations.