TABLE 2.
ΣFICs for pairwise combinations of antifungal agents tested against C. krusei ATCC 6258 suggestive of indifferent (no antagonism) interactions
| Antifungal agents | ΣFIC of the combination from laboratory:
|
Median ΣFIC (range) | CV (%)a | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |||
| AMB + PSC | 0.52 | 1.10 | 0.76 | 1.03 | 0.96 | 0.72 | 0.80 | 1.08 | 0.88 (0.52-1.10) | 22.56 |
| AMB + CSP | 1.04 | 0.93 | 0.84 | 0.92 | 1.14 | 1.11 | 0.63 | 0.84 | 0.92 (0.63-1.14) | 17.63 |
| AMB + VRC | 0.69 | 0.91 | 0.63 | 0.83 | 0.61 | 0.79 | 0.78 | 1.29 | 0.78 (0.61-1.29) | 25.35 |
| PSC + CSP | 0.98 | 0.55 | 0.63 | 0.72 | 0.79 | 1.08 | 0.65 | 0.29 | 0.68 (0.29-1.08) | 34.75 |
| PSC + VRC | 0.91 | 0.95 | 0.99 | 0.89 | 0.95 | 0.85 | 0.90 | 0.62 | 0.90 (0.62-0.99) | 13.2 |
| VRC + CSP | 0.95 | 0.93 | 0.84 | 1.19 | 0.99 | 1.32 | 0.90 | 0.57 | 0.90 (0.57-1.32) | 23.4 |
a
CV was calculated as follows: (standard deviation/mean) × 100.