TABLE 5.
Number of strains for which the MICs of isavuconazole (BAL4815) by Etest differed by ± 1, ±2, and >±3 log dilutions from those obtained by the CLSI M38-A and M27-A2 procedures
| Genus or species (no. of isolates) | No. of isolates for which the Etest MICs differed by the following no. of log dilutions:
|
% Within ±1 log2 dilutiona | % Within ±2 log2 dilutionsb | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ≥−3 | −2 | −1 | 0 | +1d | +2 | ≥+3 | |||
| Aspergillus spp. | |||||||||
| A. fumigatus (602) | 69 | 261 | 255 | 17 | 54.82 | 97.18 | |||
| A. flavus (34) | 1 | 5 | 18 | 8 | 2 | 70.59 | 94.12 | ||
| A. niger (32) | 1 | 22 | 7 | 2 | 71.87 | 93.75 | |||
| A. terreus (25) | 8 | 12 | 5 | 80.00 | 100 | ||||
| Other (9) | 1 | 2 | 4 | 2 | 33.33 | 77.78 | |||
| Overall (702) | 1 | 84 | 315 | 279 | 23 | 56.98 | 96.73 | ||
| Zygomycetes | |||||||||
| Mucor (21) | 3 | 1 | 7 | 8 | 1 | 1 | 71.43 | 80.95 | |
| Rhizopus (12) | 3 | 2 | 6 | 1 | 75.00 | 75.00 | |||
| Absidia (6) | 1 | 3 | 1 | 1 | 83.33 | 100 | |||
| Cunninghamella (4) | 2 | 1 | 1 | 75.00 | 100 | ||||
| Syncephalastrum (2) | 2 | 0 | 100 | ||||||
| Overall (45) | 6 | 1 | 10 | 19 | 3 | 5 | 1 | 71.11 | 84.44 |
| Scedosporium spp. | |||||||||
| S. prolificans (6) | 6 | 100 | 100 | ||||||
| S. apiospermum (16) | 13 | 2 | 1 | 6.25 | 18.75 | ||||
| Overall (22) | 13 | 2 | 6 | 1 | 31.82 | 40.91 | |||
| Fusarium spp. (20) | 1 | 4 | 4 | 9 | 1 | 1 | 65.00 | 85.00 | |
| Candida spp. | |||||||||
| C. albicans (69)c | 2 | 2 | 3 | 47 | 10 | 4 | 1 | 85.51 | 94.20 |
| C. parapsilosis (84) | 3 | 3 | 13 | 63 | 1 | 1 | 91.67 | 96.43 | |
| C. glabrata (37) | 1 | 5 | 14 | 5 | 8 | 4 | 62.00 | 89.12 | |
| C. tropicalis (15) | 2 | 1 | 2 | 6 | 3 | 1 | 73.33 | 86.67 | |
| Other (7) | 1 | 6 | 85.71 | 85.71 | |||||
| C. krusei (5) | 2 | 1 | 1 | 1 | 80.00 | 80.00 | |||
| Overall (217) | 7 | 7 | 25 | 138 | 19 | 13 | 7 | 84.33 | 93.09 |
a
Percentage of strains included between dilutions −1 and +1.
b
Percentage of strains included between dilutions −2 and +2.
c
One strain of C. albicans did not grow on RPMI agar.
d
MIC by the E-test 1 dilution step lower.