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Effect of IL-1β or IL-18 on the SLIGKV-NH2-induced production of IL-8 in NHEK. A synergistic increase in IL-8 production was induced by the combination of SLIGKV-NH2 with IL-1β but not with IL-18. No significant changes were observed in the presence of the control peptide VKGILS-NH2. Empty bars, control; filled bars, SLIGKV-NH2-treated cells; gray bars, VKGILS-NH2-treated cells. Student's two-tailed t test was performed for the statistical analysis of data. ns, not significant.
