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Effect of macrolides on the synergistic production of IL-8 induced by both IL-1β and SLIGKV-NH2 in NHEK. The synergistic induction of IL-8 was suppressed by 10 μM RXM (A), EM (B), or CAM (C). Empty bars, control; filled bars, SLIGKV-NH2-treated cells. Student's two-tailed t test was performed for the statistical analysis of data. *, P < 0.005; **, P < 0.05.
