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Inhibition of recombinant IN by L-708,906. The inhibitory effect of L-708,906 against IN with three mutations (T66I L74M S230R) (B) was evaluated and compared to that of the wild-type (WT) IN enzyme (A). In panel A, lane 1, DNA substrate control; lanes 2 to 8, DNA substrate in the presence of 0, 2.48, 0.82, 0.27, 0.09, 0.03, and 0.01 μM L-708,906. In panel B, lanes 1 to 7, DNA substrate in the presence of 0, 2.48, 0.82, 0.27, 0.09, 0.03, and 0.01 μM L-708,906.
