TABLE 2.
Antibacterial effect of tomopenem at standard (106 CFU/ml) inoculum
| Strain/CLSI MIC (mg/liter) | Dose (mg)a | Log change in viable count (log CFU/ml) at:
|
Time (h) to kill:
|
AUBKC (log CFU/ml·h)
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 12 h | 24 h | 36 h | 48 h | Max | 99% | 99.9% | 0-24 | 0-48 | ||
| 5956/0.06 | 750 | −4.1 ± 0.5 | −4.3 ± 0.4 | −4.5 | −4.5 | −4.5 | 4 | 6 | 27.6 ± 4.5 | 27.6 ± 4.5 |
| 1,500 | −4.4 ± 0.1 | −4.4 ± 0.1 | −4.4 ± 0.1 | −4.4 ± 0.1 | −4.4 ± 0.1 | 5 | 8 | 22.7 ± 2.2 | 22.7 ± 2.2 | |
| 33921/0.5 | 750 | −3.6 ± 1.0 | −4.0 ± 0.9 | −3.9 ± 1.2 | −3.8 ± 1.3 | −4.4 ± 0.1 | 8 | 12 | 30.9 ± 7.2 | 41.0 ± 33.6 |
| 1,500 | −3.0 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −3.7 ± 0.4 | −4.2 ± 0.1 | 8 | 12 | 32.9 ± 2.1 | 38.1 ± 5.9 | |
| 33922/0.5 | 750 | −4.4 ± 0.4 | −4.1 ± 0.6 | −4.0 ± 0.9 | −3.9 ± 1.1 | −4.4 ± 0.1 | 4 | 5 | 20.2 ± 1.2 | 27.7 ± 15.7 |
| 1,500 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | 4 | 5 | 16.9 ± 1.0 | 16.9 ± 1.0 | |
| 33827/2 | 750 | −4.4 ± 0.1 | −3.6 ± 1.6 | −3.7 ± 1.7 | −3.3 ± 2.2 | −4.4 ± 0.1 | 4 | 7 | 27.4 ± 7.3 | 44.9 ± 42.3 |
| 1,500 | −4.3 ± 0.1 | −4.0 ± 0.6 | −4.0 ± 0.6 | −3.6 ± 0.7 | −4.3 ± 0.1 | 6 | 12 | 28.1 ± 2.0 | 35.5 ± 10.3 | |
| 33829/2 | 750 | −4.5 ± 0.1 | −4.5 ± 0.1 | −4.5 ± 0.1 | −4.5 ± 0.1 | −4.5 ± 0.1 | 5 | 12 | 25.0 ± 3.2 | 25.0 ± 3.2 |
| 1,500 | −4.5 ± 0.1 | −4.2 ± 0.4 | −4.0 ± 0.8 | −3.8 ± 1.2 | −4.5 ± 0.1 | 7 | 12 | 30.0 ± 1.4 | 37.4 ± 11.5 | |
| 33820/16 | 750 | −3.9 ± 0.3 | −4.2 ± 0.2 | −4.2 ± 0.2 | −4.2 ± 0.2 | −4.2 ± 0.2 | 7 | 12 | 28.6 ± 2.8 | 28.6 ± 2.8 |
| 1,500 | −4.2 ± 0.1 | −4.2 ± 0.1 | −3.8 ± 0.6 | −4.2 ± 0.1 | −4.2 ± 0.1 | 6 | 12 | 23.4 ± 0.9 | 23.4 ± 0.9 | |
| 33815/16 | 750 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | 6 | 12 | 22.7 ± 2.8 | 22.7 ± 2.8 |
| 1,500 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | −4.2 ± 0.1 | 3 | 5 | 12.5 ± 0.4 | 12.5 ± 0.4 | |
a
Doses were given 8hly.