TABLE 3.

Antibacterial effect of tomopenem at high (10⁸ CFU/ml) inoculum

Strain/MIC (mg/liter)	Dose (mg)a	Log change in viable count (log CFU/ml) at:					Time (h) to kill:		AUBKC (log CFU/ml·h)
		12 h	24 h	36 h	48 h	Max	99%	99.9%	0-24	0-48
33922/0.5	750	−4.5 ± 0.4	−5.0 ± 0.3	−5.5 ± 0.5	−5.8 ± 0.2	−6.0 ± 0.2	12	12	71.5 ± 3.1	81.5 ± 10.8
	1,500	−1.5 ± 0.1	−5.0 ± 0.3	−5.2 ± 0.5	−4.1 ± 0.1	−5.5 ± 0.4	16	24	100.1 ± 1.7	124.7 ± 8.8
33827/2	750	−3.8 ± 0.2	−5.2 ± 0.2	−5.0 ± 0.3	−5.9 ± 0.4	−6.2 ± 0.1	12	12	77.4 ± 4.3	87.9 ± 9.2
	1,500	−3.4 ± 0.1	−5.8 ± 0.6	−6.0 ± 0.2	−5.9 ± 0.1	−6.1 ± 0.1	12	12	84.4 ± 3.4	93.5 ± 1.8
33815/16	750	1.7 ± 0.2	−4.3 ± 0.6	−5.5 ± 1.3	−5.0 ± 1.5	−5.5 ± 1.2	16	24	100.0 ± 4.8	119.0 ± 28.9
	1,500	−1.5 ± 0.2	−4.1 ± 0.1	−3.9 ± 0.2	−3.9 ± 0.1	−4.2 ± 0.1	16	24	103.5 ± 5.5	152.6 ± 7.1

^aDoses were given 8hly.