TABLE 5.
Relationship between T>MIC (% of dosing interval) and Δ24 for tomopenem against MSSA (one strain) and MRSA (five strains) - inoculum 106 CFU/ml
| T>MIC (%) for: | Strain
|
Mean ± SD (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| MSSA 5965 | MRSA 33922 | MRSA 33829 | MRSA 33827 | MRSA 33820 | MRSA 33815 | ||
| Static effect | 6.0 | 1.3 | 12.1 | 15.4 | 5.9 | 5.3 | 8 ± 5 (2-13) |
| 1-log drop in count | 7.4 | 3.4 | 16.8 | 24.4 | 9.9 | 8.6 | 12 ± 8 (4-20) |
| 2-log drop in count | 8.7 | 5.4 | 20.8 | 31.2 | 14.5 | 12.5 | 16 ± 9 (6-25) |
| 3-log drop in count | 10.1 | 9.4 | 21.5 | 43.0 | 20.4 | 17.1 | 21 ± 13 (8-35) |
| 4-log drop in count | 12.8 | 21.5 | - | 61.0 | 36.2 | 29.6 | 32 ± 18 (9-55) |
| R2 model | 0.999 | 0.989 | 0.968 | 0.997 | 0.998 | 0.989 | 0.936 |