TABLE 6.
Relationship between T>MIC (% of dosing interval) and Δ24 for tomopenem against MSSA (1 strain) and MRSA (3 strains) - inoculum 108 CFU/ml
| T>MIC% for: | Strain
|
Mean ± SD (95% CI) | |||
|---|---|---|---|---|---|
| MSSA 5965 | MRSA 33922 | MRSA 33827 | MRSA 33815 | ||
| Static effect | |||||
| 1-log drop in count | 3.4 | 2.0 | 19.5 | 1 | 6.4 ± 8.7 (−7.4 to 20.4) |
| 2-log drop in count | 7.4 | 4.7 | 39.6 | 2 | 13.4 ± 17.6 (−14.6 to 41.4) |
| 3-log drop in count | 12.8 | 8.7 | 59.3 | 3.3 | 20.9 ± 25.7 (−19.3 to 61.9) |
| 4-log drop in count | 20.1 | 15.0 | 79.1 | 6.5 | 30.1 ± 33.1 (−22.4 to 82.9) |
| R2 model | 0.98 | 0.89 | 0.96 | 0.96 | |