TABLE 6.

Guidelines for the treatment of CNS tuberculosis^a

Drug	Pediatric daily dose	Adult daily dose	Duration (mo)	CNS penetration
First-line therapy
Isoniazid	10-15 mg/kg (300 mg)	5 mg/kg (300 mg)	9-12	Yes
Rifampin	10-20 mg/kg (600 mg)	10 mg/kg (600 mg)	9-12	Yes, with inflammation
Rifabutin	Unknown	5 mg/kg (300 mg)	9-12	Yes, with inflammation
Pyrazinamide	15-30 mg/kg (2.0 g)	15-30 mg/kgb (2.0 g)	2	Yes
Ethambutol	15-20 mg/kg (1.0 g)	15-20 mg/kgb (1.0 g)	2	Yes, with inflammation
Second-line therapy
Cycloserine	10-15 mg/kg/day (1.0 g/day)	10-15 mg/kg/day (1.0 g/day)	18-24	Yes
Ethionamide	15-20 mg/kg/day (1.0 g/day)	15-20 mg/kg/day (1.0 g/day)	18-24	Yes
Streptomycinc	20-40 mg/kg/day (1.0 g)	15 mg/kg/day (1.0 g), 10 mg/kg/day in patients >59 yr of age (750 mg)	6	Yes, with inflammation
Amikacin-kanamycinc	15-30 mg/kg/day (1.0 g)	15 mg/kg/day (1.0 g), 10 mg/kg/day in patients >59 yr of age (750 mg)	6	Yes, with inflammation
Capreomycinc	15-30 mg/kg/day (1.0 g/day)	15 mg/kg/day (1.0 g), 10 mg/kg/day in patients >59 yr of age (750 mg)	6	Yes, with inflammation
p-Aminosalicylic acid	200-300 mg/kg/day in 2 to 4 divided doses (10 g)	8-12 g/day in 2 or 3 divided doses	18-24	Yes, low levels
Levofloxacin	Unknownd	500-1,000 mg	18-24	Yes, low levels
Moxifloxacin	Unknownd	400 mg	18-24	Yes, low levels
Gatifloxacin	Unknownd	400 mg	18-24	Yes, low levels

^aData adapted from reference 3; maximum doses are in parentheses.

^bSee reference 3 for suggested doses.

^cIntravenous route only.

^dLong-term use of fluoroquinolones in children has not been approved.