FIG. 1.

In vivo imaging of luciferase expression following inoculation of 10¹⁰ viral particles of rAd5-Luc in wild-type (wt) and nu/nu mice. The mice (n = 4) were inoculated by i.m., i.p., s.c., and i.n. routes. (A and C) Photon emissions from a representative mouse from each group are shown at different time points following inoculation; the emissions were measured using an RLU scale. (B and D) Mean (± standard errors of the mean) RLU values were transformed into protein expression using recombinant luciferase protein as a standard. The time after DNA inoculation is shown in a log scale to highlight early events.