Table 8.

Overall response rate and PFS in 4 randomized trials comparing gemcitabine to gemcitabine plus other cytotoxic agent

Reference	Year	n	Treatment regimen	ORR (%)	p	Median PFS/TTP (mo)	p
Oettle	2005	282	Gemcitabine	7.1	0.004	3.3	0.111
		283	Gemcitabine + Pemetrexed	14.8		3.9
Rocha Lima	2004	180	Gemcitabine	4.4	< 0.001	3.0	0.352
		180	Gemcitabine + Irinotecan	16.1		3.5
Stathopoulos	2006	70	Gemcitabine	10	0.387	2.9	0.795
		60	Gemcitabine + Irinotecan	15		2.8
O'Reilly	2004	174	Gemcitabine	7.1	--	3.8	0.22
		175	Gemcitabine + Exatecan	8.2		4.1

ORR = overall response rate; PFS = progression-free survival; TTP = time-to-progression;