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. Author manuscript; available in PMC: 2009 Mar 1.
Published in final edited form as: Dev Biol. 2008 Jan 4;315(1):243–255. doi: 10.1016/j.ydbio.2007.12.035

Figure 6.

Figure 6

PTK787/ZK222588 treatment of B.schlosseri systems. Different systems from the same genotype were treated at diverse blastogenetic stages with PTK787/ZK222588 dissolved in DMSO (E) and with only DMSO (A) 3 hours before the complete ampullaectomy (t0-3h). (B) and (F), surgical ablation of the ampullae and marginal vessel in the untreated and treated samples respectively. Morphological analysis after 48 (t+48h) and 120 hours (t+120h) of the vascular regeneration in the controls (C), (D) and in the treated (G) and (H). Close-up of untreated (I) and treated (J) samples 120 hours past the ampullaectomy: after a week the system injected with 0.5/0.9 μl of 20μM PTK787/ZK222588 did not show vascular regeneration. Dots underline the edge of the cut. Scale bar 1mm.