Table 2. Hematologic features of Hfe-/- Hfe tg animals.
Red blood cell parameters were measured in 8 week-old female mice
| Genotype | Hgb (g/dl) | Hct (%) | MCV (fL) | MCH (pg) | RDW (%) | Retic (%) | CHr (pg) |
|---|---|---|---|---|---|---|---|
| WT (N=12) | 14.7 ± 0.1 | 46.8 ± 0.4 | 49.6 ± 0.3 | 15.6 ± 0.1 | 13.4 ± 0.2 | 3.6 ± 0.2 | 16.3 ± 0.1 |
| Hfe-/- (N=14) | 15.6 ± 0.2 | 50.6 ± 0.8 | 52.6 ± 0.6 | 16.3 ± 0.1 | 13.1 ± 0.2 | 3.6 ± 0.2 | 16.2 ± 0.7 |
| Hfe-/- Hfe tg (N=6) | 12 ± 0.3 | 39.9 ± 0.8 | 38.2 ± 0.6 | 11.5 ± 0.1 | 22.2 ± 0.7 | 4.5 ± 0.4 | 12.8 ± 0.2 |
| P, Hfe-/- vs Hfe-/- Hfe tg | P<0.001 | P<0.001 | P<0.001 | P<0.001 | P<0.001 | NS | P<0.001 |
| P, WT vs Hfe-/- Hfe tg | P<0.001 | P<0.001 | P<0.001 | P<0.001 | P<0.001 | NS | P<0.001 |
| P, WT vs Hfe-/- | P<0.001 | P<0.001 | P<0.001 | P<0.001 | NS | NS | NS |
WT = wild type; NS = not significant, tg = transgene. The measured parameters were hemoglobin (Hgb), hematocrit (Hct), mean cell volume (MCV), mean cell hemoglobin (MCH), red cell distribution width (RDW), reticulocyte count (Retic), and reticulocyte mean cell hemoglobin (CHr). Values are mean ± SEM. P-values (Student’s T-test) were calculated using Microsoft Excel.