TABLE 3.

FAMILY-BASED ANALYSIS OF ASSOCIATION BETWEEN TSLP SINGLE-NUCLEOTIDE POLYMORPHISMS AND TOTAL SERUM IgE AMONG CHILDREN WITH ASTHMA IN COSTA RICA AND CHILDHOOD ASTHMA MANAGEMENT PROGRAM

			Costa Rica				CAMP
				FBAT	Z score (P value)			MAF	FBAT	Z score (P value)
rs Number	Alleles	Location	MAF	All	Males	Females	FBATI P value		All	Males	Females	FBATI P value
rs991035	A > G	5′ genomic	0.35	—	—	—	—	—
rs17551370	G > A	5′ genomic	0.10	—	—	—	—
rs10455025	A > C	5′ genomic	0.31	—	—	—	—
rs2289276	C > T	5′ untranslated	0.29	—	—	−2.19 (0.013)	0.009	0.26	—	—	−2.66 (0.004)	0.002
rs2289277	C > G	Intronic	0.41	—	—	—	—
rs11466749	A > G	Exonic	0.11	—	—	—	—

Definition of abbreviations: CAMP = Childhood Asthma Management Program; FBAT = family-based association test; FBATI = family-based test of interaction; MAF = minor allele frequency.

Em dashes (—) indicate nonsignificant results (P values > 0.05). For clarity only P values < 0.05 are shown. Minus signs (−) refer to negative association with the minor allele and total serum IgE.