FIG. 5.

Results of ELISAs measuring serum IgG and sputum IgA to rMsp22, rMsp75, and rMsp78 in serum and sputum supernatants of samples from adults with COPD who acquired and cleared M. catarrhalis. The patients tested are shown on the x axis. The percent changes from preacquisition to postclearance are shown on the y axis. Cutoff values were determined by averaging the difference between 10 control pairs of sera or sputum from patients who had never been colonized with M. catarrhalis, and these values are indicated by the horizontal lines. Samples that generated OD₄₅₀ values less than 0.1 were considered not to represent a significant level of antibody, and values of zero were assigned.