TABLE 3.
Sequence variations detected in coding regions of RepMP1-containing genes in clinical strain S1
| Locus | Nucleotide difference(s)a | Amino acid difference(s) |
|---|---|---|
| MPN037 | 1 (A145 to C) | 1 (T49 to P) |
| MPN094 | 1 (G331 to A) | 1 (E111 to K) |
| MPN100 | 2 (C132 to T*, G434 to T) | 1 (G145 to V) |
| MPN130 | Missing | |
| MPN137 | Distal portion of MPN138/7 fused gene (nucleotides 373 to 594 and 616 to 687 remain); 2 (T493 to C*, C575 to T) | Amino acids 125 to 228 remain; amino acids 203 to 209 are missing; 1 (R192 to C162) |
| MPN138 | Proximal portion of MPN138/7 (nucleotides 1 to 233 remain) | Amino acids 1 to 78 remain |
| MPN139 | 1 (C402 to T*) | 0 |
| MPN204 | 1 (A166 to C) | 1 (T56 to P) |
| MPN283 | 1 (G310 to A) | 1 (E104 to K) |
| MPN368 | 3 (G253 to A*, G286 to A, G440 to A) | 2 (E96 to K, G147 to D) |
| MPN410 | 1 (A57 to G*) | 0 |
| MPN465 | 0 | 0 |
| MPN484 | 0 | 0 |
| MPN501 | 0 | 0 |
| MPN524 | 2 (T265 to G, G366 to T); nucleotides 395 to 415 are missing | 2 (V89 to K, K122 to N); amino acids 132 to 138 are missing |
| MPN655 | 6 (T114 to C*, C203 to A, C208 to A, C210 to T, G219 to C*, A517 to G) | 3 (L68 to P, P70 to T, S173 to G) |
a
An asterisk indicates a silent mutation.