TABLE 1.
B. burgdorferi infection in MyD88 KO mice and controlsa
| Mouse strain | No. of mice with result/total no. of mice
|
||
|---|---|---|---|
| Arthritis | Positive culture for B. burgdorferi | Anti-B. burgdorferi IgG | |
| MyD88 KO | 4/8 | 8/8 | 8/8 |
| MyD88+/− | 2/5 | 5/5 | 7/7 |
a
Mice were infected with 106 B. burgdorferi cells and necropsied at 3 to 4 weeks postinfection. Arthritis was considered an early marker of infection. The anti-B. burgdorferi IgG response was considered positive when optical density values reached the background level of +0.2.