TABLE 1.

Broadening of epitopes following loss of control^a

Weeks postchallenge	CD8			CD4
	No. of epitopes			No. of epitopes
	Total	Lost	New	Total	Lost	New
Animal 4
140	2			1
191b	2			1
207	7		5	7		6
220b	6	1		8		1
228	6			3	5
262	8	1	3	0	3
264	5	4	1	0
Animal 5
140	3			4
191b	2	1		3	1
207	8		6	7		4
220b	3	5		7	1	1
257	0	3		0	7

^aEpitopes were mapped by enzyme-linked immunospot assay, followed by intracellular cytokine staining analyses (14).

^bAt weeks 191 and 220, animals were retested by intracellular cytokine staining for previously mapped epitopes (14).