FIG. 7.

EBNA3C and c-Myc synergistically modulate transcription from c-Myc target promoters. Increasing amounts (0 to 200 ng) of either c-Myc or EBNA3C expression constructs were cotransfected with 0.25 μg of either a wild-type or a mutant c-Myc-responsive promoter/reporter construct. Differences in protein and reporter construct levels between samples were balanced by the corresponding empty vectors. Cells were harvested ∼24 h later and tested for luciferase reporter activity using a luminometer. Plots are representative of data from similar repeat experiments.