TABLE 3.
Summary of capsid mutant phenotypes
| Virus | Core accumulation | Encapsidation specificitya |
|---|---|---|
| Wild type | Yes | Yes |
| CΔ(96-100) | Yes | No |
| CΔ(91-100) | No | No |
| CΔ(101-105) | Yes | No |
| CΔ(106-110) | No | No |
| CΔ(101-110) | No | No |
| CΔ(97-106) | Yes | No |
| CΔ(107-113) | No | No |
| K99E | Yes | No |
| K99E/R105E | Yes | No |
| R103A | Yes | No* |
| R105A | Yes | No |
| R103A/R105A | No | No |
| L108D | No | No* |
| L110N | No | No* |
| L108D/L110N | No | No* |
Asterisks indicate that, in these mutants, the binding affinities of the CP(81-112) mutant proteins for the encapsidation signal RNA were not significantly affected relative to the affinity of the wild-type protein.