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. 2008 Mar 3;28(9):2971–2979. doi: 10.1128/MCB.01695-07

FIG. 3.

FIG. 3.

Effect of β-cell-specific ablation of TSC2 on glucose-stimulated insulin secretion in mice at 8 weeks of age. Blood glucose (A) and plasma insulin (B) concentrations during oral glucose tolerance tests are shown for control (open circles; n = 9), βTSC2+/− (gray circles; n = 5), and βTSC2−/− (black circles; n = 10) mice. (C) Acute insulin response to intraperitoneal administration of glucose (3 mg per gram of body weight) in control (open circles; n = 4) and βTSC2−/− (filled circles; n = 4) mice. All data are means ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001 for comparison with the corresponding values for control mice.