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Pathological changes, detected by H&E, TUNEL, and parafibromin staining, in tamoxifen-treated Cre-ER/Hrpt2L/L mice prior to death. All the tissues from the tamoxifen-treated Cre-ER/Hrpt2L/L mice had more TUNEL staining but less expression of parafibromin compared with control mice. In the tamoxifen-treated Cre-ER/Hrpt2L/L mice, there was reduced glandular tissue in the salivary glands (H&E) but significantly increased cell death in the liver and kidneys (H&E).
