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Role of histone deacetylation on repression of RARE reporter activity by Acinus-S′. The bar graph indicates relative RARE reporter gene activity levels from transfected Cos-7 cells treated with ethanol (EtOH), 1 μM RA, or 100 nM TSA for 24 h. The change in normalized Luc activity was calculated relative to cells that were transfected with empty vector DNA (no Acinus-S′) and treated with ethanol and vehicle (set as 1). Error bars indicate standard deviations.
