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. Author manuscript; available in PMC: 2008 Apr 14.
Published in final edited form as: Biochem Biophys Res Commun. 2006 Oct 30;351(4):883–889. doi: 10.1016/j.bbrc.2006.10.102

Fig 2.

Fig 2

CDDO-Im pretreatment attenuates LPS induced ROS levels as well as expression of cytokines (Tnf-α, Il-6) and chemokines (Mcp1, Mip2) exclusively in nrf2 +/+neutrophils. A) LPS induced ROS levels in nrf2 +/+ and nrf2 −/− peritoneal neutrophils pretreated with CDDO-Im. Peritoneal neutrophils were pretreated with CDDO-Im for 12 h and then stimulated either with vehicle or LPS (100 ng/ml). Each bar is the mean ± SD (n=3) of values presenting the integration of the area under curve for 60 min expressed in counts. B) LPS induced cytokines and chemokines expression in nrf2 +/+ and nrf2 −/− peritoneal neutrophils pretreated with CDDO-Im and or NAC. Peritoneal neutrophils were pretreated either with CDDO-Im or NAC for 12 h then stimulated either with vehicle and or LPS (100 ng/ml) for 3 h. Data presented are mean fold change ± SD (n=3). * Differs from vehicle control of the same genotype; †, differs from LPS treated of the same genotype (P<0.05).