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. Author manuscript; available in PMC: 2009 Mar 7.
Published in final edited form as: J Mol Biol. 2008 Jan 5;376(5):1360–1376. doi: 10.1016/j.jmb.2007.12.063

Figure 1. Location and structure of the alcohol binding site in LUSH.

Figure 1

(a) Structure of the LUSH-butanol complex showing the position of butanol (cyan). (b) close up view of the alcohol binding site in the LUSH-butanol complex. The oxygen of alcohols forms potential hydrogen bonds with S52 and T57, while the alkyl chain of butanol forms contacts with residues F64, L76, F113, and W123. Figure based on PDB ID 1OOH. Ethanol binds to the same site. Distances between the T57 Oγ and alcohol O are 2.51 Å while the distance between the S52 Oγ and alcohol O is 3.18 Å.