Skip to main content
. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Semin Immunol. 2007 Nov 28;19(6):377–382. doi: 10.1016/j.smim.2007.10.009

Figure 3.

Figure 3

Proposed model of IL-17 signaling in human airway epithelium. IL-17RA and IL-17RC can associate to potentially form a heterodimeric receptor. Antibodies against IL-17RA depicted in light blue can effectively block IL-17A and IL-17F. However due to the relatively lower affinity of soluble IL-17RA:Fc depicted in dark blue, can bind can neutralize IL-17A but is ineffective blocking IL-17F resulting in only partial abrogation of IL-17 induced CXC chemokines.