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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Biomaterials. 2008 Feb 7;29(13):2113–2124. doi: 10.1016/j.biomaterials.2007.12.048

Figure 8.

Figure 8

Protein stability after encapsulation and release from dissolving microneedles. (a) Circular dichroism spectrum of untreated lysozyme (negative control); lysozyme encapsulated in CMC microneedles and released by dissolution in PBS; lysozyme encapsulated in CMC microneedles and released by dissolution in PBS after 2 months storage at room temperature; and lysozyme denatured at 80ºC for 30 min (positive control). (b) Enzymatic activity of untreated lysozyme (A, negative control); lysozyme mixed with dissolved placebo CMC microneedles (B, negative control); lysozyme encapsulated in CMC microneedles and released by dissolution in PBS (C); lysozyme encapsulated in CMC microneedles and released by dissolution in PBS after 2 months storage at room temperature (D).