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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Biomaterials. 2008 Feb 7;29(13):2113–2124. doi: 10.1016/j.biomaterials.2007.12.048

Table 1.

Simulated critical buckling load, Pcr, of CMC and PLA microneedles as a function of microneedle shape, length, and base width/diameter.

Conical (800 μm length)
Pyramidal (600 μm length)
Conical (600 μm length)
Diameter* (μm) Pcr (N)
Width* (μm) Pcr (N)
Diameter* (μm) Pcr (N)
CMC PLA CMC PLA CMC PLA
50 0.0004 0.0020 50 0.0020 0.010 50 0.0007 0.0035
75 0.0019 0.0096 75 0.0087 0.044 75 0.0034 0.017
100 0.0061 0.031 100 0.026 0.13 100 0.011 0.055
200 0.10 0.51 200 0.36 1.8 200 0.18 0.91
300 0.5 2.6 300 1.8 8.9 300 0.94 4.7
400 1.7 8.4 400 5.5 28 400 3.0 15
600 8.6 43 500 13 67 500 7.3 37
800 27 137 600 27 137 600 15 76
*

Diameters and widths are reported at the base of the microneedles, which taper to a tip of approximately 25 μm diameter.