TABLE 2.
Clinical occurrence of the rtV173L mutation in 70 GenBank wild-type HBV sequences and at baseline in adefovir dipivoxil trials
| Trial | Patient population | No. of patients tested | No. (%) of patients with rtV173L at baseline |
|---|---|---|---|
| GenBank 70a | Wild-type HBV clone infected | 70 | 0 (0) |
| GS-98-435 | Lamivudine-resistant, chronic hepatitis B transplant patients | 122 | 23 (19) |
| GS-99-460ib | Lamivudine-resistant, chronic hepatitis B, HIV-coinfected patients | 35 | 8 (23) |
| GS-00-461 | Lamivudine-resistant, chronic hepatitis B patients | 59 | 5 (9) |
a
Seventy wild-type HBV sequences from the GenBank database; isolates of all HBV genotypes (A to G) are included. Individual accession numbers are listed in reference 40.
b
The occurrence of rtV173L was previously reported to be higher in this study; however, the study investigators have confirmed that the data provided in this table are accurate (4; V. Thibault and Y. Benhamou, unpublished data).