FIG. 6.

Identification of residues on the FG loop important for MAb binding. The sequence of HPV-16 and HPV-31 L1 are compared (A). Residues that are predicted to be >45% surface accessible are indicated with arrows and bold type is used to indicate nonconserved residues. CAMVIR-1, H16.V5, H16.E70, and H16.U4 were tested for binding to VLPs that were serially diluted prior to testing. The normalized binding values are presented (B), with each MAb represented by bars, as described in the legend to Fig. 4 (error bars show standard deviations).