FIG. 1.
Expression of the HIV-1 transgene in murine lymph node DC. Transgene expression in lymph node DC of CD4C/HIVMutA transgenic mice was detected by in situ hybridization with an HIV-1-specific antisense riboprobe (a to c) and a sense probe as a control (d). The expression of MHC II (a and b) and CD11c (c) on the DC was determined by immunohistochemistry and appears in brown. Magnification, ×100; bar, 25 μm. Data are representative of at least nine experiments, each involving cells from pooled lymph nodes of sex- and age-matched transgenic (n = 3) and control nontransgenic (n = 3) mice.