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. 2003 Nov;77(21):11733–11744. doi: 10.1128/JVI.77.21.11733-11744.2003

TABLE 1.

DC recovery from peripheral lymph nodes of CD4C/HIVMutA transgenic mice

Expt no. Mouse age (mo) No. of micea Nontransgenic
Transgenic
Total no. (105) % of DC
Total no. (105) % of DC
CD11bneg-int CD11bhi CD8α+ CD11bneg-int CD11bhi CD8α+
1 1.5 2 1.3 81 15 35 3.0 75 21 20
2 2 2 0.7 69 29 25 0.7 65 35 16
3 2 2 0.8 65 29 25 0.8 60 39 24
4 2 4 1.4 66 34 ND 0.8 59 41 ND
5 2.5 2 0.5 49 48 ND 0.5 38 60 ND
6 2.5 2 1.5 58 16 22 0.7 50 16 9
1 to 6 1.5-2.5 14 1.0 ± 0.2 65 ± 4 28 ± 5 27 ± 3 1.0 ± 0.4 58 ± 5* 35 ± 6** 17 ± 3
7 3 3 0.6 68 32 ND 0.3 45 55 ND
8 3 2 1.4 69 29 ND 0.5 24 75 ND
9 3 4 2.2 37 64 ND 1.0 22 79 ND
10 3 2 3.0 72 27 23 2.4 68 31 17
11 3.5 3 1.3 83 17 ND 1.5 72 28 ND
12 4 2 1.2 60 34 ND 1.0 46 50 ND
13 4 3 0.6 71 29 10 0.5 46 54 6
14 5.5 2 1.7 74 23 ND 1.0 53 46 ND
7 to 14 3-5.5 21 1.5 ± 0.3 67 ± 5 32 ± 5 17 ± 7 1.0 ± 0.2 47 ± 6* 52 ± 6** 12 ± 6
a

The number indicated applies to both nontransgenic and transgenic mice (i.e., 2 indicates two of each). Total, data represent absolute numbers of DC recovered per mouse. CD11b levels of expression appear as high (CD11bHi) or negative to intermediate (CD11bneg-int). The data are presented as mean ± standard error of the mean. ND, not done. Each experiment was done with sex-matched littermate controls. *, P = 0.023, **, P = 0.03 (two-way analysis of variance).