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. Author manuscript; available in PMC: 2009 Mar 1.
Published in final edited form as: Bioorg Med Chem. 2007 Nov 19;16(5):2676–2686. doi: 10.1016/j.bmc.2007.11.039

Scheme 3. Reagents and conditions.

Scheme 3

(i) 22, DIAD, PPh3, THF, rt, 1 h, 96%; (ii) NaOMe, MeOH, rt, 16 h, 84%; (iii) PDC, DMF, rt, 20 h, 94%; (iv) TFA/H2O (9/1), 1 h, rt, 94%; (v) 30, DIAD, PPh3, THF, rt, 1 h; b) TFA, CH3Cl, rt, 30 min, 51% yield in two steps; (vi) PDC, DMF, rt, 20 h, 80%; (vii) TFA/H2O (9/1), 2 h, rt, 90%.