. Author manuscript; available in PMC: 2009 Mar 1.

Published in final edited form as: Bioorg Med Chem. 2007 Nov 19;16(5):2676–2686. doi: 10.1016/j.bmc.2007.11.039

Table 1.

Irradiation and NOE data for pseudouridine at 25 °C and uridine derivatives at 40 °C

Compound	Proton irradiated	NOE (%)	Compound Proton	irradiated	NOE (%)
Ψ	H6	H1′ (5.8)	U	H6	H1′ (4.3)
syn		H2′ + H3′ (1.9)	anti		H2′ + H3′ (10.2)
	H1′	H6 (5.9)		H1′	H6 (4.5)
	H2′	H6 (2.2)		H2′	H6 (6.9)
	H3′	H6 (0.8)		H3′	H6 (2.5)

m¹Ψ	H6	H1′ (9.1)	acp³U	H6	H1′ (4.0)
syn		H2′ + H3′ (2.4)	anti		H2′ + H3′ (9.7)
	H1′	H6 (7.6)		H1′	H6 (4.0)
	H2′	H6 (2.6)		H2′	H6 (6.7)
	H3′	H6 (2.1)		H3′	H6 (2.1)

m¹acp³Ψ	H6	H1′ (6.5)	acb³U	H6	H1′ (5.0)
syn		H2′ + H3′ (3.6)	anti		H2′ + H3′ (9.2)
	H1′	H6 (5.1)		H1′	H6 (4.9)
	H2′	H6 (2.2)		H2′	H6 (7.3)
	H3′	H6 (0.7)		H3′	H6 (2.1)

m¹hb³Ψ	H6	H1′ (7.9)	hb³U	H6	H1′ (4.4)
syn		H2′ + H3′ (4.3)	anti		H2′ + H3′ (8.1)
	H1′	H6 (5.5)		H1′	H6 (4.0)
	H2′	H6 (2.5)		H2′	H6 (5.5)
	H3′	H6 (0.5)		H3′	H6 (1.9)

Ψm	H6	H1′ (3.5)	cp³U	H6	H1′ (5.2)
syn		H2′ + H3′ (1.2)	anti		H2′ + H3′ (7.5)
	H1′	H6 (1.4)		H1′	H6 (4.8)
	H2′	ND		H2′	H6 (6.5)
	H3′	ND		H3′	H6 (2.1)

ND: not detectable