. Author manuscript; available in PMC: 2009 Apr 1.

Published in final edited form as: Comp Biochem Physiol C Toxicol Pharmacol. 2007 Dec 4;147(3):316–323. doi: 10.1016/j.cbpc.2007.11.008

TABLE 1.

Characteristics of CD-1 Mouse and Holtzman Rat Pups

Characteristic	Diet	Rat	Mouse	Mouse-2
		P26	P27	P27
Body mass, g	Cu+	91.1 ± 3.4	19.9 ± 0.7	21.8 ± 1.0
	Cu−	72.7 ± 6.2^*	16.1 ± 1.8^*	14.5 ± 1.0^*
Cp, units/L	Cu+	74.2 ± 9.22	39.6 ± 2.03	40.0 ± 3.53
	Cu−	0.85 ± 0.62^*	0.04 ± 0.03^*	0.13 ± 0.04^*
Liver Cu, μg/g	Cu+	6.53 ± 0.15	4.27 ± 0.13	3.62 ± 1.09
	Cu−	0.37 ± 0.05^*	1.38 ± 0.13^*	1.09 ± 0.06^*
Liver Fe, μg/g	Cu+	68.9 ± 3.1	111 ± 13.4	112 ± 19.3
	Cu−	60.3 ± 3.8	231 ± 19.4^*	386 ± 73.9^*
Brain Cu, μg/g	Cu+	2.61 ± 0.05	3.12 ± 0.13	2.39 ± 0.13
	Cu−	0.43 ± 0.05^*	0.59 ± 0.03^*	0.55 ± 0.04^*

Values are means ± SEM. Male rat pups (n = 3-4) and male mouse pups (n=5-6) were used. Mouse-2 was a Lactational Model only. Body mass (wt), ceruloplasmin (Cp), liver copper, liver iron and brain copper were determined as described in Methods.

Difference from Cu-Adequate (Cu+) at same age, P < 0.05 (Student’s t-test).