Table 3.

Comparison of β-sheet propensity scales

Amino acid	N	Design	RAN	Minor	Minor2	Smith	Kim	Rev_C&F
G	49	0.76	−0.11	−1.20	1.21	−0.85	0.00	0.14
A	139	−0.12	−0.22	0.00	0.00	0.00	−0.35	0.24
V	178	−0.70	−0.14	0.82	−0.94	0.17	−0.53	−0.49
I	140	−0.77	0.20	1.00	−1.25	0.02	−0.56	−0.45
L	85	0.15	0.39	0.51	−0.45	−0.24	−0.48	−0.16
F	84	−0.67	0.32	0.86	−1.08	0.16	−0.55	−0.21
M	33	−0.71	0.39	0.72	−0.90	−0.02	−0.46	−0.01
W	17	−0.14	−0.20	0.54	−1.04	−0.17	−0.48	−0.22
C	70	−0.63	−0.14	0.52	−0.78	0.08	−0.47	−0.07
S	12	1.45	0.29	0.70	−0.87	0.63	−0.39	0.06
T	107	−0.70	−0.35	1.10	−1.36	0.83	−0.48	−0.29
N	13	1.05	−0.17	−0.08	−0.52	−0.24	−0.38	0.42
Q	7	1.67	0.28	0.23	−0.38	0.04	−0.40	−0.00
H	7	1.34	0.29	0.96	−1.63	0.11	−0.46	0.19
Y	49	−0.49	0.04	−0.02	−0.37	−0.01	−0.50	−0.27
D	20	1.12	−0.15	−0.94	0.85	−0.10	−0.41	0.42
E	41	0.91	0.07	0.01	−0.23	0.31	−0.41	0.67
K	26	0.29	0.11	0.45	−0.40	−0.43	−0.41	0.31
R	81	0.34	0.06	0.27	−0.35	−0.40	−0.44	0.06
Correlation coefficients for all 19 amino acids
Design		1.00	0.18	−0.43	0.35	−0.12	0.46	0.67
RAN		0.18	1.00	0.33	−0.26	−0.00	−0.23	−0.05
Correlation coefficients for 15 amino acids (excluding S, N, Q, and H)
Design		1.00	−0.11	−0.80	0.82	−0.48	0.59	0.82
RAN		−0.11	1.00	0.25	−0.18	−0.22	−0.27	−0.05

The β-sheet propensity scales are from the following: Design, structure-based propensity scale based on computer generated sequences (this work); RAN, propensity scale based on random sequences with native amino acid composition (this work); Minor (25); Minor2 (24); Smith (26); Kim (63); and Rev_C&F [revised statistical scale based on Chou and Fasman (4)]. The β-sheet propensity values defined in this work (Design and RAN) are compared to the five other scales, and the correlation coefficients are shown for the entire set of 19 residues (excluding P) and for a subset of 15 residues (excluding the four amino acids S, N, Q, and H, under-represented).