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. 2008 Apr 14;105(16):6133–6138. doi: 10.1073/pnas.0710717105

Fig. 3.

Fig. 3.

Structural MRI data demonstrate hippocampal volume reduction in patients with schizophrenia carrying SREB2 risk alleles. (a) Effect of genotype at M01 on hippocampal volume determined with MRI VBM. G alleles are significantly associated in an allele load pattern with reduced hippocampal volume bilaterally. (b) Effect of genotype at M09 on hippocampal volume determined with MRI VBM. C alleles are significantly associated in an allele load pattern with reduced hippocampal volume bilaterally. Colors in the brain images represent t values obtained from the contrast that tests whether the slope of the regression is different from zero. Numbers on the y axis are residuals of the brain volume at the voxel location shown on the y axis after accounting for the covariates mentioned in the text.