Table 1.
Phenotypes in rescued Smad2−/− embryos
| Phenotypes | E7.5 | E8.5 | E9.5 | E10.5 | E13.5 |
|---|---|---|---|---|---|
| Tetrapoloid ⇔ Smad2−/− chimeras | (n = 22) | (n = 24) | (n = 17) | (n = 10) | ND |
| Normal appearance | 27 | 37 | 12 | 10 | ND |
| Defects in embryo turning | — | — | 59 | 60 | ND |
| Anterior truncation | — | 12* | 24† | 70‡ | ND |
| Abnormal yolk-sac/egg cylinder | 73§ | 50 | 52 | 40 | ND |
| Diploid ⇔ Smad2−/− chimeras | (n = 9) | (n = 6) | |||
| Normal | 55 | 84 | |||
| Defects in embryo turning | 44 | — | |||
| Anterior truncation | 11 | 16¶ |
Numbers in the table represent percent of embryos seen with the particular phenotype. ND, not determined; En, embryonic day.
*†One embryo with holoprosencephaly.
‡One cyclops.
§Three showed multiple egg cylinders per decidua.
¶Cyclops.