Figure 3.

Amino acid sequence alignment of the signal/propeptide and Gla domain regions of known proteins with PRGP1 and PRGP2 deduced amino acid sequences. Highly conserved residues are shaded. Strictly conserved residues are boxed. Highly conserved residues within the propeptide implicated in γ-carboxylation are denoted with an asterisk. Positions at which γ-carboxylation of glutamic acid residues is either known to occur or may occur are indicated by γ. The propeptidase cleavage site/amino terminus of mature protein is indicated with a ↓. The position of the disulfide loop within the Gla domain is also indicated. The query sequence used to search the dbEST database is shown on the bottom line. ProS, protein S; ProC, protein C; ProZ, protein Z; rACNG-RF2, conceptual translation in reading frame 2 of the cDNA encoding the rabbit aortic cyclic nucleotide-gated channel.