Table 4.

Unadjusted associations between endogenous SHBG, progesterone, estradiol to progesterone ratio, and estradiol plus estrone to progesterone ratio with menopausal symptoms

	SHBG, nmol/L		Progesterone, ng/ml		Estradiol: Progesterone Ratio		Estradiol + Estrone: Progesterone Ratio
	Geometric Mean	p-value	Geometric Mean	p-value	Geometric Mean	p-value	Geometric Mean	p-value
Headache		0.1		0.1		0.1		0.1
Yes	54.7 (50.7, 59.0)		0.717 (0.594, 0.865)		132.2 (109.0, 160.3)		335.0 (280.9, 399.5)
No	59.7 (56.1, 63.5)		0.926 (0.795, 1.077)		109.3 (93.6, 127.8)		270.5 (234.6, 311.8)
Insomnia		0.05		0.1		0.007		0.02
Yes	54.6 (50.8, 58.7)		0.750 (0.627, 0.896)		141.5 (118.0, 169.8)		341.0 (288.6, 402.8)
No	60.2 (56.4, 64.2)		0.915 (0.780, 1.073)		101.2 (86.0, 119.1)		260.0 (224.0, 301.7)
Vision problems		0.008		0.1		0.3		0.2
Yes	48.6 (43.5, 54.4)		0.691 (0.524, 0.912)		135.6 (102.0, 180.2)		347.8 (268.2, 451.1)
No	60.2 (57.1, 63.5)		0.875 (0.766, 0.999)		113.7 (99.2, 130.2)		281.9 (248.9, 319.2)
Vaginal discharge		0.8		0.8		1.0		0.9
Yes	57.2 (52.0, 62.8)		0.859 (0.681, 1.083)		116.8 (92.1, 148.1)		301.8 (243.3, 374.5)
No	57.8 (54.7, 60.2)		0.832 (0.724, 0.957)		117.8 (102.1, 135.8)		293.0 (257.2, 333.9)
Vaginal dryness		0.4		0.02		0.2		0.1
Yes	55.8 (50.1, 62.0)		0.636 (0.490, 0.836)		135.3 (103.5, 176.9)		358.9 (281.0, 458.4)
No	58.7 (55.5, 62.0)		0.904 (0.791, 1.033)		112.9 (98.4, 129.4)		277.9 (245.1, 314.9)
Irritability		0.2		0.5		0.8		0.9
Yes	56.3 (52.6, 60.2)		0.814 (0.690, 0.960)		115.3 (97.4, 136.4)		288.5 (247.3, 336.6)
No	59.8 (55.7, 64.1)		0.880 (0.740, 1.046)		118.3 (99.1, 141.2)		293.6 (249.7, 345.3)
Incontinence		0.0004		0.5		0.7		0.4
Yes	49.2 (44.5, 54.5)		0.815 (0.632, 0.952)		123.6 (95.3, 160.4)		324.2 (255.5, 411.3)
No	60.6 (57.4, 64.1)		0.844 (0.737, 0.967)		116.1 (101.0, 133.5)		286.8 (252.4, 325.8)