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. 1999 Oct 26;96(22):12679–12684. doi: 10.1073/pnas.96.22.12679

Figure 1.

Figure 1

Summary of genetic interactions with och1Δ. (A) Four MAPK cascades regulate growth and differentiation in haploid S. cerevisiae. (B) Summary of genetic interactions. (C) ste11Δ is synthetically lethal with och1Δ. (Left) Tetrads from DBL60 (STE11/ste11Δ OCH1/och1Δ) dissected onto a YPD plate and germinated at 25°C for 4 days. Ascospores 1A–3A are och1Δ single mutants, 1B–3B are ste11Δ och1Δ double mutants. After 7 days, ascospore 3B generates a microcolony of cells that fail to survive. (Right) Tetrads from DBL52 (OCH1/och1Δ). (D) Tetrads from OCH1/och1Δ diploids heterozygous for the indicated mutation. (E) Streakout of a tetrad from a ste12Δ/STE12 och1Δ/OCH1 diploid on a YPD plate. (F) Streakout (on SC-his) of kss1Δ sls1Δ (BLY443) containing vector control (pRS313) or pKSS1K42R-HIS3.