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Priming of RIP-OVAlo mice leads to the generation of OVA-specific CTL. A RIP-OVAlo mouse or a nontransgenic littermate (A) was injected with OVA peptide in complete Freund’s adjuvant. Then, 1 wk later, their spleens were removed and cultured in vitro with OVA-loaded spleen as previously described (8). After 6 days, cultures were assayed for OVA-specific lytic activity by assessing their ability to lyse the OVA-transfectant E.G7 (■) or EL4 (□) cells.
