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Efficacy of sTGF-βR in blocking the actions of TGF-β. (A) Exogenous TGF-β produces a dose-dependent blockade of mink lung epithelial cell proliferation. (B) Dose-dependent inhibition of TGF-β (250 pg/ml) by soluble TGF-β receptor, measured as release of cells from the inhibitory effect of the cytokine. Serial dilutions of the sTGF-βR were incubated with a known amount of TGF-β1 (250 pg/ml) and added to the wells. Thymidine incorporation was determined over 4 hr.
