Table 1.
Comparison | Nucleotide differences
|
Amino acid differences*
|
||||||
---|---|---|---|---|---|---|---|---|
Promoters† | 12S rRNA | 16S rRNA | tRNAs | I | III | IV | V | |
European–Japanese | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
European–African | 0 | 6 | 5 | 5 | 0 | 0 | 0 | 0 |
European–common chimp | 2 | 35 | 81 | 59 | 102 | 22 | 19 | 16 |
European–pigmy chimp | 2 | 30 | 95 | 57 | 99 | 24 | 17 | 15 |
European–gorilla | 2 | 33 | 116 | 89 | 127 | 21 | 26 | 21 |
European–orangutan | 4 | 81 | 164 | 155 | 265 | 38 | 54 | 54 |
Common chimp–pigmy chimp | 2 | 11 | 37 | 31 | 60 | 15 | 5 | 12 |
Common chimp–gorilla | 1 | 40 | 104 | 89 | 143 | 27 | 22 | 30 |
Common chimp–orangutan | 6 | 87 | 157 | 153 | 285 | 41 | 53 | 59 |
The table, modified from Horai et al. (9), shows a comparison between human mtDNA (European, Japanese, and African) and nonhuman primate mtDNA (common chimpanzee, pigmy chimpanzee, gorilla, and orangutan). Data are derived from sequences deposited in GeneBank (9, 31).
Amino acid substitutions that have been described as polymorphic in humans (32) were excluded from the analysis. Different subunits of the same oxidative phosphorylation complex (I–V) were pooled.
Promoter regions (33) correspond to human mtDNA positions 396–411 (light-strand promoter) and 554–568 (major heavy-strand promoter).